The Morten Meyer Lab
Our research program is mainly focused on identifying molecular and biochemical signals regulating cell fate decisions and understanding the pathogenesis of Parkinson’s disease (PD).
We place particular emphasis on formation of functional dopaminergic neurons with midbrain characteristics - the cell type that degenerates in PD.
Using stem cells and stem cell lines derived from developing human brain tissue (neural stem cells) and patients with PD (induced pluripotent stem cells), we pursue investigating the following topics:
interaction between stem cells, neurons and glial cells.
the pathogenesis of PD by molecular and functional characterization of dopaminergic neurons and glial cells produced from patient-derived induced pluripotent stem cells.
Our general ambitions are to advance the understanding of the molecular mechanisms underlying PD, discover potential disease-modifying targets and contribute to the development of new therapies.
To achieve our goals, we use stem cells, cell lines, primary cells, organotypic brain slice cultures, and animal models of PD. Our methods include biochemical/molecular assays, stereotactic cell transplantation, behavioral analyses, histological and bioimaging techniques.